January 2017 MIMM Journal Club
Jan 13, 2017
1280 Main Street West, Hamilton, Canada
12:30PM to 1:30PM
Date(s) - 13/01/2017
12:30 pm - 1:30 pm
The next meeting will be held on Friday, January 13th, 2017 at 12:30pm in Room 204 of the Psychology Building at McMaster University!
Dr. Laurel Trainor’s graduate student, Sarah Lade, will lead a discussion on the article by Martinez-Molina et al., 2016 entitled “Neural correlates of specific musical anhedonia”. Abstract listed below.
Martínez-Molina, N., Mas-Herrero, E., Rodríguez-Fornells, A., Zatorre, R. J., & Marco-Pallarés, J. (2016). Neural correlates of specific musical anhedonia. Proceedings of the National Academy of Sciences, 113(46), E7337-E7345.
Although music is ubiquitous in human societies, there are some people for whom music holds no reward value despite normal perceptual ability and preserved reward-related responses in other domains. The study of these individuals with specific musical anhedonia may be crucial to understand better the neural correlates underlying musical reward. Previous neuroimaging studies have shown that musically induced pleasure may arise from the interaction between auditory cortical networks and mesolimbic reward networks. If such interaction is critical for music-induced pleasure to emerge, then those individuals who do not experience it should show alterations in the cortical-mesolimbic response. In the current study, we addressed this question using fMRI in three groups of 15 participants, each with different sensitivity to music reward. We demonstrate that the music anhedonic participants showed selec- tive reduction of activity for music in the nucleus accumbens (NAcc), but normal activation levels for a monetary gambling task. Further- more, this group also exhibited decreased functional connectivity between the right auditory cortex and ventral striatum (including the NAcc). In contrast, individuals with greater than average response to music showed enhanced connectivity between these structures. Thus, our results suggest that specific musical anhedonia may be associated with a reduction in the interplay between the auditory cortex and the subcortical reward network, indicating a pivotal role of this interaction for the enjoyment of music.
Hamilton, Ontario, L8S 4L8